Hellow....
Been 1 whole freaking day since i slept.....been thinking a lot lately....
check out what I dug up recently....
RETINOIC ACID
Vitamin A, in the retinoic acid form, plays an important role in gene transcription. Once retinol has been taken up by a cell, it can be oxidized to retinal (by retinol dehydrogenases) and then retinal can be oxidized to retinoic acid (by retinal oxidase). The conversion of retinal to retinoic acid is an irreversible step, meaning that the production of retinoic acid is tightly regulated, due to its activity as a ligand for nuclear receptors. Retinoic acid can bind to two different nuclear receptors to initiate (or inhibit) gene transcription: the retinoic acid receptors (RARs) or the retinoid "X" receptors (RXRs). RAR and RXR must dimerize before they can bind to the DNA. RAR will form a heterodimer with RXR (RAR-RXR), but it does not readily form a homodimer (RAR-RAR). RXR, on the other hand, readily forms a homodimer (RXR-RXR) and will form heterodimers with many other nuclear receptors as well, including the thyroid hormone receptor (RXR-TR), the Vitamin D3 receptor (RXR-VDR), the peroxisome proliferator-activated receptor (RXR-PPAR) and the liver "X" receptor (RXR-LXR).The RAR-RXR heterodimer recognizes retinoid acid response elements (RAREs) on the DNA whereas the RXR-RXR homodimer recognizes retinoid "X" response elements (RXREs) on the DNA. The other RXR heterodimers will bind to various other response elements on the DNA. Once the retinoic acid binds to the receptors and dimerization has occurred, the receptors undergo a conformational change that causes co-repressors to dissociate from the receptors. Coactivators can then bind to the receptor complex, which may help to loosen the chromatin structure from the histones or may interact with the transcriptional machinery. The receptors can then bind to the response elements on the DNA and upregulate (or downregulate) the expression of target genes, such as cellular retinol-binding protein (CRBP) as well as the genes that encode for the receptors themselves.
Gives me an idea...use retinoic acid to treat leukemia.....hmm.....
The Prince Of Emotions....
- Muted Emotions
- Malaysia
- 2005..The year I lost everything I ever had...as I try to stand up again I realized that there are more hypocrites in this world than supporters.. But I'm sure thankful for those who are with me today. I'm born on 13th june 1989, male(yup..male...got it?! 100% male!) and I've seen and experienced things far beyond possible. Some envy me for certain attributes I possess, some just want to see me fall(too bad, I'm gonna keep holding till YOU fall suckers!)..some look up to me...I really respect them..thanks for everything guys. I'm a biomedical student at Unisel and currently a Training Medical Laboratory Scientist at Gribbles Pathology Seremban Like to think critically and assume that nothing is impossible..listening to my mp3s(Emo,screamo,punk,metal,goth),playing online and lan games..jamming.. and hanging out with my besties..I'm an Emo Of Course...I like the way I am... Got a big time ego problem but I can mellow down.. Always emotional.. takes serious matters seriously.. trying to have fun... Revengeful against a disease.. Maybe I would disappear once my job is done...thats all..enjoy reading my blog... c ya...(^-,^)
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