Behold...You now Enter The Twisted World Of Joel...

Yeap...hahaha...well...welcome to my page...you'll find various stuffs that may/may not be useful to you...I would keep updating this blog whenever I'm free so be sure to check it out often aite?
do comment on my posts...DO NOT POST OFFENSIVE COMMENTS!thank you and enjoy your stay...

(Stand On The Shoulder Of Giants)

The Prince Of Emotions....

My photo
Malaysia
2005..The year I lost everything I ever had...as I try to stand up again I realized that there are more hypocrites in this world than supporters.. But I'm sure thankful for those who are with me today. I'm born on 13th june 1989, male(yup..male...got it?! 100% male!) and I've seen and experienced things far beyond possible. Some envy me for certain attributes I possess, some just want to see me fall(too bad, I'm gonna keep holding till YOU fall suckers!)..some look up to me...I really respect them..thanks for everything guys. I'm a biomedical student at Unisel and currently a Training Medical Laboratory Scientist at Gribbles Pathology Seremban Like to think critically and assume that nothing is impossible..listening to my mp3s(Emo,screamo,punk,metal,goth),playing online and lan games..jamming.. and hanging out with my besties..I'm an Emo Of Course...I like the way I am... Got a big time ego problem but I can mellow down.. Always emotional.. takes serious matters seriously.. trying to have fun... Revengeful against a disease.. Maybe I would disappear once my job is done...thats all..enjoy reading my blog... c ya...(^-,^)

Friday, April 8, 2011

Fairies..Legends?..or Facts?

Ahoy there.....
don't have to explain about fairies..but maybe a little...
fairies are extraterrestrial beings..described as little butterfly like humans..with magical powers..like seen in most fantasy movies and books..
And I recently came pass something in wikipedia...2 sisters took photos of them with fairies at their backyard???!!!
Seriously???
Unbelivable right?but Kodak has issued "certificate of authentication"...citing that their one of the pictures is real..

Monday, January 17, 2011

The Very basics of Hematology..the blood groups..

Ahoy there.....

As we all know..there are 4 main groups for the human blood...

A
B
AB
O

And for each of these..there's something called the rhesus factor..(which makes it now to 8 subgroups)

A+/-
B+/-
AB+/-
O+/-

Thats right..always remember..even O blood has + or -...keep that in mind..
Now these blood groups are all coded by glycoprotiens(sugars)..protiens..carbohydrates or glycolipids (varying between the blood group types..these substances make up antigens on the surface of the red blood cells (surface antigens)...these are randomly coded by our genetics..and they are permanent for a lifetime..in rare cases such as Demi-Lee Brennan's case is the 1st ever case of blood group change in history...A complete blood type would describe a full set of 30 substances on the surface of Red blood cells..and an individual's blood type is one of the many possible combinations of blood-group antigens..Across the 30 blood groups characterized by the International Society Of Blood Transfusions (ISBT)..over 600 different blood-group antigens have been found..but many of these are very rare and/or are mainly found in certain ethnic groups..these are called special antigens..amongst the common (but still rare) special antigens are...

Kell system
Duffy system
Kid system
I and P systems
Bombay Blood Group

These are classified as special antigens..they are rare and demand specificity for transfusions...

In a Hematology lab..we determine blood groups in order to help us decide what type of blood can be transfused to the patient..for example..an individual with type A+ blood can receive blood from A+ and O+ type only...wrong transfusion will lead to transfusion reaction (a condition where the patient's body starts rejecting the donor's blood)..reason? in the blood plasma..there's ANTIBODIES..antibodies are "gate keepers" that attack anything that doesn't look friendly..including a different subgroup of red cells...below I'll describe each corresponding plasma antibodies in the ABO system..

A: Anti-B antibodies..
B: Anti-A antibodies
AB: NO ANTIBODIES
O : BOTH Anti-A and Anti-B antibodies

Therefore..its always important to perform a cross matching research do determine if the donor's blood is suitable for the recipient..(tomorrow I will enclose a video on how blood typing is done and how cross matching is done)..Also remember..if there is a transfusion reaction EVEN IF THE PROPER ABO BLOOD IS TRANSFUSED TO THE PATIENT..the transfer will be stopped immediately and serology tests would be done to determine special antigens (such as mentioned above)..these are called "warm antibody tests" or "RBC serology tests"..

It is always important that you keep these infos in mind so that in the future you will know what actually is going on when a medical personnel performs blood grouping and talks about blood transfusion reactions to you..So the next time you donate blood or you need a blood transfusion..you'll be aware of the criticality of these tests..hehe..don't underestimate the job of a Scientists..if it isn't because of us..doctors would be facing a hard time making desicions for you..=)

Here I've provided several diagrams related to this post for easier understanding..if there's any questions or corrections to this post..please do inform me in the comment box..I'll answer or edit the post a.s.a.p...

See yea...^_^






Blood Type Compability


















Symptoms Of Hemolytic Reactions (Tranfusion Reactions)















The ABO Blood Group System

The revolution

Ahoy there.....

Starting from today..I'll post informational posts regarding medical.. laboratory tests..how to read tests results and how to ensure your doctor's diagnosis is correct..also..I will share some interesting things related to punk rock culture and music...so I'm guessing you guys already get a hint on what this whole blog is gonna be about from now on eh?ahahaha....not to forget..for those playing games on computer,ps2 or psp or ps3..there will be some news about games as well..so keep following me..lets make this blog grow and lets make a difference..let us all tell the world that all it takes is the ability to dream to make the world a better place..^_^

1...
2...
3...

GO!!!

Wednesday, September 1, 2010

Back again..

Gonna turn this blog into an intellectual one...
anything that relates to current issues of medicine such as new findings or current researches will be posted here..
also..I'll be posting any really interesting events that come up in my life from now on...
there would also probably be posts about anime..games..music and so on..(probably..these will be the 2nd most common posts on this blog since my life revolves around them..hahaahha...)
alright..thats all for now...
I'll update soon...

(^_^)"

find me on facebook: sk8ter_death@hotmail.com

Tuesday, May 4, 2010

Regardless....

Ahoy there.....

Okies..so its been really some time since I actually wrote something here..sorry guys..its just that I've been extremely busy with myself..hahaha...well..it isn't easy afterall..life sure isn't a bed of roses huh..

Anyways...I would like to ask everyone a question....

Mountain Dew...for those who are malaysians...does anyone remember?
I mean,....it was in malaysian market during the 90's..but then removed..I was a very small kid then but I grew fond of it..but none of my family members and friends actually remembers..

Anyone here remembers?

Saturday, August 29, 2009

Loveless

Ahoy there.....

Check out This poem....
its called loveless...by Jack Skellington...
Its read by Genesis Rhapsodos in Final Fantasy 7 Crisis Core...
Its a beautiful poem...so enjoy....


Prologue
When the war of the beasts brings about the world’s end
The goddess descends from the sky
Wings of light and dark spread afar
She guides us to bliss, her gift everlasting.


Act I
Infinite in mystery is the gift of the goddess
We seek it thus, and take it to the sky
Ripples form on the water’s surface
The wandering soul knows no rest.

Act II
There is no hate, only joy
For you are beloved by the goddess
Hero of the dawn, Healer of worlds
Dreams of the morrow hath the shattered soul
Pride is lost
Wings stripped away, the end is nigh.

Act III
My friend, do you fly away now?
To a world that abhors you and I?
All that awaits you is a somber morrow
No matter where the winds may blow
My friend, your desire
Is the bringer of life, the gift of the goddess
Even if the morrow is barren of promises
Nothing shall forestall my return.

Act IV
My friend, the fates are cruel
There are no dreams, no honor remains
The arrow has left the bow of the goddess
My soul, corrupted by vengeance
Hath endured torment, to find the end of the journey
In my own salvation
And your eternal slumber
Legend shall speak
Of sacrifice at world’s end
The wind sails over the water’s surface
Quietly, but surely.

Act V
Even if the morrow is barren of promises
Nothing shall forestall my return
To become the dew that quenches the land
To spare the sands, the seas, the skies
I offer thee this silent sacrifice.

Wednesday, July 15, 2009

The Itch..(Not The 7 Year Itch)

Ahoy there.....

So...have u ever wondered why we have an itch?well as far as medical researches go, no scientists have actually found the proper reason to why we have an itch....its kinda a wonder why we do u know that's why I'm publishing this post...i have done lots of thinking over this imponderable and I've came up with 3 seemingly logical reasons....

1)itch indicates irritation-the easiest way for mother nature to alert us that something is irritating us and to get rid of the irritant....ironic...

2)itch could be caused by body hair- simple....body hair itching our skin....

3) Get rid of dead cells-this could be the most logical scientific explanation...our body sheds dead cells every 5 minutes...this is normal because every now and then cells should be replaced to maintain optimum homeostasis(that's regulation) therefore dead cells are shed off the body as dirt(that's why our body gets sticky and we need a bath)..now dead cells are excotic food for parasites and vermins such as louse and mites..just like we all love pizza..(right??)..when these bad boys start feasting, they end up feasting on live cells too thats when we get redness on our skin without scratching the redness is caused by inflammation(part of our body's weapons againts the enemy)..we get an itch to firstly get rid of the tiny patch of dead cells(dirt) before these buggers have dinner on our skin...secondly we get an itch to engage inflammation and protect the body against these vermins in case we forget to throw their meal away before their dinnertime...itching could be our body's defense against eczema....

So, the next time you get an itch, relax....its time to take a bath....if you are not lazy that is..hahahahaha....

(p/s: this has nothing to do with the 7 year itch...)

Monday, May 4, 2009

Ahoy there.....
By the way....the patient I've been monitoring is now perfectly healthy and happily living her life as a normal teenager.....
Good to see her happy......
She asked: "So....you saved me....why?"
"Guess thats my job kiddo.....afterall I took the oath...cant break it..."
"Is it the oath? or some other reasons?cause i could see a great relive in your eyes...like you've woken up from a nightmare"
"you dont need to know all that..go on.....live....."
"Good luck...thanks for your breath of live.."
"thank God...not me...honestly He doesnt want to see us all like these..."
"true.....keep up that optimism....."
"See ya...."

Hmmm.........

I'm Gonna keep Running....

Ahoy there.....
Guess sometimes shit does happen eh?lately I had terrible headaches,noisebleed,bloody cough n terrible migrain....So, as usual iI used all those skillz i stued in class and started off a differential diagnosis on myself (symptoms and all the diseases that produce those symptoms)...Visited a dictor and that guy said im most probably having cephalosacroma (brain tumor)....yeah...as I expected...but im mot gonna die yet!!!! not yet.....not until i cure leukemia....not until I become the greastest doctor ever alive and not until I go down amonst the greatest humans ever alive...in the Nobel Prize list....
Keep Fighting The Good Fight...
Never Back Down.....

Monday, November 24, 2008

A new Life For Jennifer Shee

Ahoy there.....

S0o....the patient is fine now....
current blood picture shows her white blood cells are back to normal...
she completely healthy and ready to be dispatched anytime...
but...hmmm.....
saving 1 was a relive...
I still lost 2 lives.....
guess I just gotta move on....no point looking back at what's lost....
Move on....thats all I can do...

Good luck Jen....

Tuesday, November 18, 2008

Current Report On The Patient Suffering From Hairy Cell Leukemia

Ahoy there.....

Ok...like the title says....I will write down the current report...

Heart Rate Monitored since Yesterday....

42 bpm(3pm@17 nov)

35bpm(5pm@17 nov)

28 bpm(9pm@17 nov)

35bpm (10am@18 nov)

47bpm (3pm@18nov)

Patients respiration has been increasing since we injected her with all-trans retinoic acid 0.5 miligrams...However we can't come up with any assumptions yet till we get the next reading about 5pm today.....

will come back to this soon...

Monday, November 17, 2008

Retinoic Acid 101

Hellow....

Been 1 whole freaking day since i slept.....been thinking a lot lately....
check out what I dug up recently....


RETINOIC ACID


Vitamin A, in the retinoic acid form, plays an important role in gene transcription. Once retinol has been taken up by a cell, it can be oxidized to retinal (by retinol dehydrogenases) and then retinal can be oxidized to retinoic acid (by retinal oxidase). The conversion of retinal to retinoic acid is an irreversible step, meaning that the production of retinoic acid is tightly regulated, due to its activity as a ligand for nuclear receptors. Retinoic acid can bind to two different nuclear receptors to initiate (or inhibit) gene transcription: the retinoic acid receptors (RARs) or the retinoid "X" receptors (RXRs). RAR and RXR must dimerize before they can bind to the DNA. RAR will form a heterodimer with RXR (RAR-RXR), but it does not readily form a homodimer (RAR-RAR). RXR, on the other hand, readily forms a homodimer (RXR-RXR) and will form heterodimers with many other nuclear receptors as well, including the thyroid hormone receptor (RXR-TR), the Vitamin D3 receptor (RXR-VDR), the peroxisome proliferator-activated receptor (RXR-PPAR) and the liver "X" receptor (RXR-LXR).The RAR-RXR heterodimer recognizes retinoid acid response elements (RAREs) on the DNA whereas the RXR-RXR homodimer recognizes retinoid "X" response elements (RXREs) on the DNA. The other RXR heterodimers will bind to various other response elements on the DNA. Once the retinoic acid binds to the receptors and dimerization has occurred, the receptors undergo a conformational change that causes co-repressors to dissociate from the receptors. Coactivators can then bind to the receptor complex, which may help to loosen the chromatin structure from the histones or may interact with the transcriptional machinery. The receptors can then bind to the response elements on the DNA and upregulate (or downregulate) the expression of target genes, such as cellular retinol-binding protein (CRBP) as well as the genes that encode for the receptors themselves.

Gives me an idea...use retinoic acid to treat leukemia.....hmm.....

Sunday, November 16, 2008

Good morning...

Ok...so i haven't slept for the whole night....
am i insomniac?guess not...
just that i cant sleep without dreaming of.....her....
i mean...it's been 4 years now.....
still dreaming of her....
still could feel the ghost of her.....
Amie.........

Saturday, November 15, 2008

Healing microorganism?!

Ahoy there.....

Okay...i just got up from my sleep about an hour ago when i got this superb idea to help my research....
I'm gonna use algae to treat leukemia!!!!!!!!=)
I know it sounds strange heh? but as i was reading certain articles, people assume that chlorella, spirulina and other forms of blue-green algae has a high amount of beta-carotene (vitamin A) that could act as anti-cancer properties therefore, worth the shot....
Next i should refer to my microbiology lecturer on how to culture such algae...it would be easier if we could culture them instead of buying them in large amounts...its not easy to buy them though so it would be better if we could culture them....
I've personally never taken spirulina but some say they taste like kiwi juice?hmmmm...
by the way..I'm gonna read up more...so I'll get back here a.s.a.p with more details about algae...

Till then.....

(I Am Emo)

New Look!(For Now)

Ohio Gozaimas.....

Aha! re-customized my blog.....
By the way...i really like that emo girl on my blog title....
she's cute aint she?
reminds me of someone really meaningful to me somewhat 4years back....
hmmmmm.....
long story.....aint got the mood to tell you guys now....
do remind me about it aite?
thats all for now though...will get back a.s.a.p...

c ya....

(Emo Is My Way)

p.s: do scroll down to the very end of the page....I've got some cool music vidz, trivias on immunology and news feeds....

Something new? Maybe I should keep in consideration?

Ahoy there.....

Wow....guess what...while i was surfing the net looking up for some info about leukemia to help my research, I found out something really2 astonishing...
I'm not gonna tell u guys about it...I suggest you read it yourself...

VITAMIN A FOUND TO CURE THOSE WITH LEUKEMIA

In the medical field, many doctors are astonished by the new benefits of Vitamin A. Vitamin A has been observed to have profound effects upon conditions such as macular generation as well as other health condition. Recently, at the University of Texas, M.D. Anderson Cancer Center, researchers have found that Vitamin A strong affects those who suffer with leukemia. During the trial conducted, researches observed that without the assistance of chemotherapy, Vitamin A helped to cure 1/3 of patients with a rare form of leukemia, called acute promyelocytic leukemia.

In order to enhance the vitamin's bioavailability injected vitamin A, which was renamed to be a "biological agent", into the adipose tissue (fat) of these patients. Researchers felt the retinoic acid, was not being absorbed the body so they decide to circumvent the absorption process. According to Dr. Gabriel Lopez-Berestein, M.D., a professor in the Department of Experimental Therapeutics, when the all-trans retinoic acid is placed in a lipid carrier it is not metabolized and stays longer in the tissues. According to various sources, 10 of the 34 participants remained cancer-free after five years of observance. Some of the remaining participants were able to combat the leukemia with the combination of Vitamin A and chemotherapy. These number are pretty amazing provide that patient are able to live long-term, drug free lives. In the overall trial, many of the patients are in remission, though they had to supplement their therapy with chemotherapy.

This type of advancement or finding, is a great tool that physician can work with when treating patients with APL or other applicable leukemias. More people would be willing to seek treatment if they did not have to undergo chemotherapy. Many patients can not tolerate the persistent side effects of the chemotherapy such as hair loss, chronic fatigue, nausea, and vomiting.

Though there is some skeptism about the strength of the results. Many researchers do concur that Vitamin A is potent at helping the body to defeat certain types of cancer.

These type of findings strength the argument about the benefit of alternative medicine. Many believe that there are various organic compounds found in certain natural products that we constantly overlook. It is believe by some that certain natural nurtitional supplements such spirulina, chlorella, and licorice root have anti-cancer properties once consumed.

Source: University of Texas, MD Anderson Cancer Center


(Hmmm.....where could I obtain pure spirullina and chlorella?)

Friday, November 14, 2008

Hi and Hellow.....

So....this is my first time blogging on blogspot...well i have a xanga account its just that its been ages since i last checked it...somewhat 5years ago perhaps?whatever...just gonna continue bloggin here then...
lets see.....erm....just want to tell you readers that on my blog you would find many pictures snapped by me...which somehow relates to what i basically do everyday...thanks to my best buddy ever my Sony Ericsson K800i, you can find 3.2 megapix photos here(i know its nothing much buy c'mon...i'm a freakin biologist not a photographer!)..
well....erm...thats about it for now....Will get back here tomorrow probably...c ya!

(EMO IS MY WAY OF LIFE)